Chromosomal Instability in Gastric Cancer Biology
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چکیده
منابع مشابه
Chromosomal Instability in Gastric Cancer Biology
Gastric cancer (GC) is the fifth most common cancer in the world and accounts for 7% of the total cancer incidence. The prognosis of GC is dismal in Western countries due to late diagnosis: approximately 70% of the patients die within 5 years following initial diagnosis. Recently, integrative genomic analyses led to the proposal of a molecular classification of GC into four subtypes, i.e.,micro...
متن کاملChromosomal instability and human cancer.
Genetic instability is a defining feature of human cancer. The main type of genetic instability, chromosomal instability (CIN), enhances the rate of gross chromosomal changes during cell division. CIN is brought about by mutations of CIN genes, i.e. genes that are involved in maintaining the genomic integrity of the cell. A major question in cancer genetics is whether genetic instability is a c...
متن کاملChromosomal Instability, Aneuploidy, and Cancer
The link between aneuploidy and cancer has been recognized over a century ago (1). Abnormalities in chromosome copy numbers arise from persistent errors in chromosome segregation during cell division, a process known as chromosomal instability (CIN) (2). CIN is a principal contributor to genetic heterogeneity in cancer (3) and is an important determinant of clinical prognosis and therapeutic re...
متن کاملGenetic Instability in Gastric Cancer
Gastric cancer remains a worldwide burden as a second leading cause of cancer death in both sexes (Globocan, 2011; Nobili et al., 2011). Although its incidence is in decline in developed countries, it is still the fourth most common malignancy in the world, behind cancers of the lung, breast, colon, and rectum (Globocan, 2011). The fall in its incidence is attributed mainly to the decline of th...
متن کاملMulti-Layered Cancer Chromosomal Instability Phenotype
Whole-chromosomal instability (W-CIN) - unequal chromosome distribution during cell division - is a characteristic feature of a majority of cancer cells distinguishing them from their normal counterparts. The precise molecular mechanisms that may cause mis-segregation of chromosomes in tumor cells just recently became more evident. The consequences of W-CIN are numerous and play a critical role...
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ژورنال
عنوان ژورنال: Neoplasia
سال: 2017
ISSN: 1476-5586
DOI: 10.1016/j.neo.2017.02.012